In order to lower a high K+ level with Kayexalate, does there need to be a successful bowel movement (i.e. The recommended maintenance dose range is from 5 g every other day to 15 g daily. Do not mix with potassium containing liquids or food (eg, orange juice, bananas) Suspension may be chilled to improve palatability. Too much potassium in your blood, a condition called hyperkalemia, can happen suddenly or because of an ongoing condition like kidney disease. Discontinue or decrease the dose of LOKELMA if serum potassium is below the desired target range. Hi. Hi there -- Quick question. Hyperkalemia – high potassium – is a condition that can lead to serious health issues. Rectal Administration. is the K+ excreted with the stool) The reason I ask is that we have a patient w/K+ 5.4. For moderate elevation (6 to 7 mEq/L), shift potassium intracellularly with Glucose plus insulin, Sodium bicarbonate, and Nebulized albuterol For severe elevation (>7 mEq/L with toxic ECG changes), you need to shift potassium into the cells and eliminate potassium from the body. “This really casts doubt that Kayexalate was doing very much at all,” according to Sterns. Another review (Nephrol Dial Transplant 2003; 2215–2218) has questioned the theoretical basis of Kayexalate’s potassium-lowering effect. Patiromer - a new potassium binder - Replaces Kayexalate. Sodium Polystyrene Sulfonate (SPS, Kayexalate, Cation-Exchange Resin) Other methods of lowering Potassium are preferred. Administer cleansing enema beforehand For mild elevation (5 to 6 mEq/L), remove potassium from the body with Furosemide and Kayexalate. I had a patient with a potassium of 6.4, was given oral Kayexalate, then three days later had a potassium of 2.0. Sodium polystyrene sulfonate (SPS) or Kayexalate is a cation‐exchange resin that is commonly employed to lower total body potassium in patients with mild to moderate hyperkalemia.1214 It removes potassium from the gut in exchange for sodium. Patiromer is a relatively new potassium binder and studies showed it is superior to Kayexalate which has been conventionally used to lower potassium in hyperkalemia due to various causes, especially renal failure. Do not take other oral medications within 3 hr of dosing (6 hr for patients with gastroparesis or other conditions) because of potential GI binding. She is receiving Kayexalate 15gm Q6h. However, drug efficacy is unpredictable, as competition from other cations (i.e., calcium and magnesium) may reduce the potassium exchange capacity to as low as 0.4 meq per gram of SPS. SPS can be given orally or as an enema. Monitor serum potassium and adjust dose of LOKELMA at 1-week intervals or longer in increments of 5 g based on serum potassium and desired target range. LOKELMA lowers your potassium level and keeps it there with continued use.. LOKELMA is for the treatment of high levels of potassium in the blood (hyperkalemia) in adults. I was just wondering if anyone knows how long Kayexalate continues to work in the body, as I have had trouble finding half-life information on this drug. Dr Adil Ramzan. Kayexalate has marginal efficacy, is poorly tolerated, and has delayed onset of action; Kayexalate carries risk of potentially lethal bowel necrosis; Dose: 15 grams in 50-100 ml of 20% Sorbitol.

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